The 2016 Mercedes-Benz E350 sits in the later years of the W212 generation, a car known for blending executive-sedan comfort with sharp road manners and understated long-distance capability. Whether in Luxury, Sport, or wagon form, it remains a precise, modern Mercedes that rewards getting the wheel and tire setup right. This E350 uses radial tires in two primary sizes, 245/45R17 and 245/40R18, depending on sub-model and wheel package. That creates meaningful choice not just in size, but also in sidewall style, tire series, and intended use. The key is matching the tire to the exact sub-model, rim diameter, and the overall character you want from the car.
Which Tire Size Is Right for The 2016 Mercedes-Benz E350
Two primary tire sizes apply to the 2016 Mercedes-Benz E350, and the right one depends first on the exact sub-model and wheel diameter. Both are radial fitments, but one uses a 17-inch rim and the other uses an 18-inch rim. Before choosing a tire, confirm whether the car is equipped for 245/45R17 or 245/40R18, then compare the available brands, sidewall treatments, and tire series within that correct size.
Fit(s): 4Matic Luxury Sedan, 4Matic Wagon, and Luxury Sedan
Construction: Radial|Rim: 17 in
245/45R17 is a metric radial size with a 245-millimeter section width, a 45-series aspect ratio, and a fitment for a 17-inch wheel. On the 2016 Mercedes-Benz E350, it suits configurations that use the 17-inch wheel package and keeps the decision centered on selecting the right radial tire within that size. Available choices include Blackwall, raised white letter, and Redline sidewall treatments, along with series such as g-Force Sport Comp 2, g-Force Comp 2 AS, Nitto NT555 G2, Street Pro III, and Drag Radial. This size is the right starting point when your E350 is equipped with 17-inch rims and you want to compare appearance and tire character carefully.
Fit(s): 4Matic Sport Sedan, 4Matic Wagon, and Sport Sedan
Construction: Radial|Rim: 18 in
245/40R18 is a metric radial size that uses a 245-millimeter section width, a 40-series profile, and an 18-inch wheel diameter. For the 2016 Mercedes-Benz E350, this size belongs to the 18-inch wheel setup used on certain Sport and wagon applications, so wheel diameter confirmation matters before anything else. Product choices in this size include Blackwall, RWL, and Redline versions across series such as g-Force Comp 2 AS, g-Force Sport Comp 2, g-Force Phenom T/A, Nitto NT555 G2, Street Pro III, and Drag Radial. It is the size to evaluate when the car wears 18-inch wheels and you want to balance fitment, appearance, and intended use.
Sub-model fitment matters on the 2016 Mercedes-Benz E350 because tire size changes with both trim and wheel package. Some versions stay with one size, while the 4Matic Wagon can use either 17-inch or 18-inch fitment, making wheel confirmation especially important.
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2016 Mercedes-Benz E350 4Matic Luxury Sedan
The 2016 Mercedes-Benz E350 4Matic Luxury Sedan uses the 245/45R17 radial size on a 17-inch wheel setup. Tire selection here is mainly about choosing the right radial tire style, series, and sidewall treatment while staying with the correct rim diameter.
The 2016 Mercedes-Benz E350 4Matic Sport Sedan uses the 245/40R18 radial size, tying this sub-model to an 18-inch wheel package. That makes the decision more about comparing available tire series and sidewall looks within the correct size rather than choosing between multiple primary fitments.
The 2016 Mercedes-Benz E350 4Matic Wagon can use either 245/45R17 or 245/40R18, so this is the one sub-model where wheel diameter must be checked carefully. Before choosing a tire, confirm whether the wagon is on 17-inch or 18-inch wheels, then compare the available radial options in that exact size.
The 2016 Mercedes-Benz E350 Luxury Sedan uses the 245/45R17 radial fitment associated with the 17-inch wheel setup. Once that is confirmed, the real choice becomes brand, tire series, and whether a traditional Blackwall or a more distinctive sidewall treatment suits the car.
The 2016 Mercedes-Benz E350 Sport Sedan uses 245/40R18 radial tires on an 18-inch rim. Owners of this sub-model should focus on selecting among the available radial product lines and sidewall styles that match both the wheel package and the look they want.
The tire sizes listed on this page assume factory-standard vehicle configuration. The following modifications may affect tire fitment and are not reflected in this guide:
Suspension changes (lowering, lift kits, spring replacements)
Body alterations (fender modifications, custom bodywork)
If your vehicle has been modified from factory specifications, verify tire clearance before purchase.
Best 2016 Mercedes-Benz E350 Tires for Sale
Available 2016 Mercedes-Benz E350 tire options span 245/45R17 and 245/40R18 in radial construction from BFGoodrich, Nitto, M&H Racemaster, and Pro-Trac. The main points of comparison are tire series, Blackwall versus RWL or Redline sidewalls, and the rim-width specifications tied to each size.
These FAQs focus on the exact tire sizes used on the 2016 Mercedes-Benz E350, how fitment changes by sub-model, and what to compare when choosing between available radial tires, wheel diameters, sidewall styles, and road-use considerations.
Tire Size & Fitment
What tire size fits a 2016 Mercedes-Benz E350?
The 2016 Mercedes-Benz E350 uses two primary tire sizes: 245/45R17 and 245/40R18. Both are radial sizes, but they do not apply to every version of the car in the same way. Luxury Sedan models use 245/45R17, Sport Sedan models use 245/40R18, and the 4Matic Wagon can use either size depending on the wheel setup.
That means the first step is not choosing a brand or sidewall style, but confirming the exact sub-model and wheel diameter on the car. A 17-inch wheel requires the 245/45R17 fitment, while an 18-inch wheel requires 245/40R18. If the car has had wheel changes at any point, inspect the actual rim before selecting a tire.
What size rim does a 2016 Mercedes-Benz E350 use?
A 2016 Mercedes-Benz E350 uses either a 17-inch or 18-inch rim, depending on sub-model and wheel package. The 245/45R17 tire size is matched to a 17-inch rim, while the 245/40R18 size is matched to an 18-inch rim. Both fitments are radial and belong to different factory-style wheel diameter setups within the E350 range.
Rim diameter needs to be confirmed before anything else because tire size selection starts there. Even though the two sizes are close in overall diameter, they are built for different wheel diameters and cannot be treated as interchangeable. Check the sidewall on the current tire or measure the wheel directly if there is any doubt, especially on a wagon or modified car.
Do all 2016 Mercedes-Benz E350 sub-models use the same tire size?
No, the 2016 Mercedes-Benz E350 does not use one tire size across every sub-model. Luxury Sedan versions use 245/45R17, while Sport Sedan versions use 245/40R18. The 4Matic Wagon is the exception because it can be found with either 245/45R17 or 245/40R18 depending on the wheel package installed on that vehicle.
That variation matters because the real fitment divide is wheel diameter, not just trim name. A buyer looking at wagon tires should confirm whether the vehicle is actually on 17-inch or 18-inch wheels before comparing products. Once the correct size is established, then it makes sense to compare construction details, sidewall appearance, and tire series within that fitment.
Choosing the Right Tire
What should I consider when choosing a 245/45R17 tire for a 2016 Mercedes-Benz E350?
Start with the correct size and rim setup, since 245/45R17 belongs on the E350 configurations that use 17-inch wheels. From there, compare the available radial choices by intended use, tire series, sidewall style, and wheel-width compatibility. In this size, options range from Blackwall street tires to RWL, Redline, and drag-oriented offerings.
The best choice depends on how the car is driven and how the owner wants it to look. A street-focused sedan may call for a different series than a car built around a more aggressive appearance or occasional specialty use. It is also smart to compare the recommended rim-width range on each tire against the wheel actually mounted on the vehicle.
What sidewall styles are available for 2016 Mercedes-Benz E350 tires?
The available sidewall styles for 2016 Mercedes-Benz E350 tires include Blackwall, RWL, and Redline, depending on the exact tire size and product line. Blackwall is the most common presentation across both 245/45R17 and 245/40R18. RWL and Redline options appear in the Street Pro III series for both of the E350’s primary tire sizes.
Sidewall style affects appearance more than basic fitment, so it is a good comparison point once the correct size is already confirmed. A Blackwall keeps the look more understated, while RWL or Redline adds a stronger visual statement. The important step is to choose the sidewall treatment within the correct 17-inch or 18-inch tire size for the specific E350 configuration.
What brands offer tires for the 2016 Mercedes-Benz E350?
Tires for the 2016 Mercedes-Benz E350 are available from BFGoodrich, Nitto, M&H Racemaster, and Pro-Trac across its two primary sizes. Those brands cover several different tire series, including g-Force Sport Comp 2, g-Force Comp 2 AS, g-Force Phenom T/A, Nitto NT555 G2, Street Pro III, and Drag Radial. All of the available options are radial tires.
Brand choice is only one part of the decision. It helps more to compare what each brand offers in the correct size, including sidewall treatment, intended use, and rim-width specification. Once the E350’s exact fitment is confirmed, the strongest comparison is usually between series character and appearance rather than simply choosing by brand name alone.
Restoration & Appearance
Which tire should I choose for a period-style 2016 Mercedes-Benz E350?
A period-style 2016 Mercedes-Benz E350 usually starts with staying in the correct original-type size for the car’s wheel package, either 245/45R17 or 245/40R18, and keeping the radial construction that belongs to this model year. From there, the choice becomes more about sidewall appearance and tire series than about recreating an older bias-ply look.
For a more restrained factory-inspired presentation, Blackwall options will generally suit the E350’s understated design best. Redline or RWL choices create a more customized appearance that may appeal to some owners but changes the visual tone of the car. When exact originality matters, compare the tire choice against the car’s wheel package and vehicle-specific reference material.
Does correct tire fitment matter for a 2016 Mercedes-Benz E350 restoration?
Yes, correct tire fitment matters on a 2016 Mercedes-Benz E350 because the car used more than one wheel and tire package across its sub-model range. Using the proper 245/45R17 or 245/40R18 size helps preserve the stance, wheel relationship, and overall presentation that fits the car’s intended configuration. The wrong diameter package can change the visual balance immediately.
Restoration-minded owners should begin by confirming the exact sub-model and the actual wheels on the car, especially if it has changed hands or been modified. After that, the decision shifts toward appearance details such as Blackwall, Redline, or RWL. Staying with the correct size is the foundation; decorative sidewall treatment comes after fitment has been settled.
Fitment, Maintenance & Road Use
Can modifications affect tire fitment on a 2016 Mercedes-Benz E350?
Yes, modifications can affect tire fitment on a 2016 Mercedes-Benz E350 even when the tire size looks close to stock. Aftermarket wheels, changes in wheel width, altered offset, suspension lowering, or body modifications can all change how a 245/45R17 or 245/40R18 tire sits in the wheel opening. That is especially important on cars that no longer wear their original wheel package.
A modified E350 should be checked for fender clearance, inner clearance, and steering clearance before new tires are chosen. Wheel diameter alone is not enough, since width and offset can shift the tire’s position significantly. It is also wise to inspect the current setup lock-to-lock and under compression so the selected tire works with the car as it actually sits.
What should I inspect before driving a 2016 Mercedes-Benz E350 on new tires?
Before driving a 2016 Mercedes-Benz E350 on new tires, inspect the wheel size, confirm the tire size matches the sub-model, and check that the tires seat properly on the rims. Tire pressure should be set correctly, and the sidewalls and tread should be examined for shipping damage, cuts, or irregularities. Lug hardware and wheel condition also deserve a careful look.
A short test drive should include listening for rubbing and checking steering feel, especially if the car uses non-original wheels or suspension parts. After the first miles, recheck air pressure and look again for any signs of clearance problems. That quick follow-up is particularly helpful on the E350 because its fitment changes between 17-inch and 18-inch wheel packages.
How often should tires on a 2016 Mercedes-Benz E350 be inspected?
Tires on a 2016 Mercedes-Benz E350 should be inspected regularly, not just when tread looks worn. Monthly pressure checks are a good habit, and visual inspections should include tread wear, cracking, cuts, bulges, and any signs of slow air loss. Cars that are driven less often still need attention because age and storage conditions can affect tire condition over time.
An E350 that sees occasional use should also have its tires checked before longer drives and after long storage periods. Uneven wear can point to alignment, suspension, or wheel issues that deserve attention before miles add up. Keeping the tires clean, properly inflated, and protected from prolonged heat and sunlight helps preserve both appearance and roadworthiness.